Friday, December 12, 2025

Mental Health

🔷 Epileptic Encephalopathies (EE)

Definition A group of severe childhood epilepsies where epileptic activity itself causes progressive cognitive, behavioral, or developmental decline Seizures + EEG abnormalities are toxic to the brain ⭐ Core Features 👶 Early onset...

🧠Non-Compressive Myelopathy

🧠 Non-Compressive Myelopathy – High-Yield Overview Spinal cord dysfunction without external mechanical compression. Pathology is intrinsic: inflammatory, vascular, metabolic, toxic, infectious, genetic,...

🩸 Intraventricular Hemorrhage (IVH)

🧠🩸 Intraventricular Hemorrhage (IVH) in the NeuroICU – Comprehensive Review 📌 I. Introduction IVH = bleeding into the cerebral ventricular...

👁️ One and a Half Syndrome

🧠 Lesion: PPRF / Abducens nucleus + ipsilateral MLF 👁️ Ipsilateral eye: no horizontal movement 👁️ Contralateral eye: abducts only...

🧠 Drugs Causing Cognitive Impairment

⚗️ 1️⃣ Anticholinergic Medications (MOST IMPORTANT) Mechanism: Block central acetylcholine → impaired attention, memory, processing speedClinical pearl: Chronic use...

🧠 Proteinopathies of CNS

🧠 Proteinopathies of the Central Nervous System (CNS) Misfolded or abnormally aggregated proteins → neuronal dysfunction → progressive neurodegeneration.Many spread in a prion-like pattern (templated...

🧠Autoimmune paranodopathies

Autoimmune Paranodopathies (Paranodal Neuropathies) Definition:Immune-mediated neuropathies targeting paranodal axo–glial junctions, distinct from CIDP, with different pathophysiology, clinical features, and treatment response. 🔹 1️⃣ Pathophysiology 🧬 Target proteins...

🧠🧬Patho of Neurodegeneration

🧠🧬 Pathogenesis of Neurodegeneration – High-Yield Overview Definition:Progressive dysfunction and death of neurons due to interacting molecular pathways, leading to cognitive, motor, or behavioral deficits....

Living with Chronic Illness: Patient Stories of Courage and Adaptation

Living with a chronic illness is a journey fraught with challenges, resilience, and the unwavering spirit of individuals who confront these conditions daily. In...

Targeted Therapies for Hypertension: A 2023 Breakthrough

Hypertension, commonly known as high blood pressure, has long been a major health concern globally. However, 2023 brings promising advancements in hypertension management through...