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🔷 Epileptic Encephalopathies (EE)
Definition
A group of severe childhood epilepsies where epileptic activity itself causes progressive cognitive, behavioral, or developmental decline
Seizures + EEG abnormalities are toxic to the...
🧠Non-Compressive Myelopathy
🧠 Non-Compressive Myelopathy – High-Yield Overview
Spinal cord dysfunction without external mechanical compression. Pathology is intrinsic: inflammatory, vascular, metabolic, toxic, infectious, genetic, or infiltrative.
🔥 1. Inflammatory / Immune-Mediated (Most common...
🩸 Intraventricular Hemorrhage (IVH)
🧠🩸 Intraventricular Hemorrhage (IVH) in the NeuroICU – Comprehensive Review
📌 I. Introduction
IVH = bleeding into the cerebral ventricular system
Historically fatal; modern NeuroICU care 💉...
👁️ One and a Half Syndrome
🧠 Lesion: PPRF / Abducens nucleus + ipsilateral MLF
👁️ Ipsilateral eye: no horizontal movement
👁️ Contralateral eye: abducts only (half movement) + nystagmus
🔼🔽 Vertical movement:...
🧠 Drugs Causing Cognitive Impairment
⚗️ 1️⃣ Anticholinergic Medications (MOST IMPORTANT)
Mechanism: Block central acetylcholine → impaired attention, memory, processing speedClinical pearl: Chronic use in elderly ↑ dementia risk (dose-dependent)Examples:
Antihistamines:...
🧠 Proteinopathies of CNS
🧠 Proteinopathies of the Central Nervous System (CNS)
Misfolded or abnormally aggregated proteins → neuronal dysfunction → progressive neurodegeneration.Many spread in a prion-like pattern (templated...
